Yes. You will need to complete a new UCAS application; a previous application cannot be reused.
You can apply to start the first year of a different course at another university or college, or if you'd like to study a similar course, you can apply for entry to the second or third year at a different university or college, as long as the course content is similar.
It's a good idea to discuss your application with the new university or college you're interested in.